货号 |
bsm-54335R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-CD46 antibody |
中文名称 |
Rabbit Anti-CD46 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
免疫学,糖蛋白, |
英文别名 |
MCP; CD46 antigen; CD46 molecule; CD46 molecule complement regulatory protein; Complement membrane cofactor protein antibody MCP; Measles virus receptor; Membrane cofactor protein; Membrane cofactor protein precursor; MIC 10; MIC10; TLX; TRA2.10; Trophobl |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ICC |
推荐稀释比例 |
WB=1:1000-5000,IHC-P=1:50-200,IHC-F=1:50-200,ICC=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
4C3 |
抗体来源 |
Rabbit |
理论分子量 |
36 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human CD46 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa.
Isoform 2: Secreted (Probable). |
Tissue |
Present only in testis (at protein level). |
SIMILARITY |
Contains 4 Sushi (CCP/SCR) domains. |
Function |
May be involved in the fusion of the spermatozoa with the oocyte during fertilization. |
Post-translational |
May be O-glycosylated (By similarity).
N-glycosylated. |
SWISS |
P15529 |
Gene ID |
4179 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities which play important roles in the regulation of the complement activation pathway. CD46 is widely distributed on blood cells, endothelial cells, epithelial cells and tumor cell lines. CD46 exists as many isoforms in a variety of tissues. The antigen has a broad distribution and is present on leukocytes, platelets, endothelial cells, epithelial cells and fibroblasts. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. It is expressed on thymocytes, B cells, monocytes, granulocytes, NK cells, platelets, epithelial and endothelial cells. |