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货号 | bs-2533R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-Versican antibody |
中文名称 | Rabbit Anti-Versican antibody |
研究领域 | 细胞生物,免疫学,信号转导,转录调节因子 |
英文别名 | Versican; CSPG2; DKFZp686K06110; ERVR; GHAP; PG-M; WGN; WGN1; versican core protein isoform 1 precursor; ; Large fibroblast proteoglycan; Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; CSPG2; Glial hyaluronate binding |
反应物种(已验证) | Mouse,Rat |
反应物种(预测) | Human,Dog,Pig,Cow,Horse |
产品应用(已验证) | IHC |
产品应用(可推荐) | IF,ELISA |
推荐稀释比例 | Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 370 |
细胞定位 | 细胞外基质,分泌型蛋白 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from human Versican |
抗原表位 | 3301-3396/3396 |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Secreted, extracellular space, extracellular matrix. |
Tissue | Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissu |
SIMILARITY | Belongs to the aggrecan/versican proteoglycan family. Contains 1 C-type lectin domain. Contains 2 EGF-like domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 2 Link domains. Contains 1 Sushi (CCP/SCR) domain. |
SUBUNIT | Interacts with FBLN1 (By similarity). |
Function | May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. |
Post-translational | Phosphorylation sites are present in the extracellular medium. |
DISEASE | Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optic |
SWISS | P13611 |
Gene ID | 1462 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |