货号 |
bs-1615R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Cathepsin D antibody |
中文名称 |
Rabbit Anti-Cathepsin D antibody |
研究领域 |
细胞生物,免疫学,神经生物学,合成与降解,细胞粘附分子,细胞外基质, |
英文别名 |
Cathepsin D light chain; CatD; CathepsinD; Cathepsin-D; CLN10; CPSD; CTSD; Lysosomal aspartyl peptidase; MGC2311; CATD_HUMAN. |
反应物种(已验证) |
Rat |
反应物种(预测) |
Human,Mouse,Dog,Pig,Cow,Rabbit |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
11/38/45 |
细胞定位 |
细胞浆,分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Cathepsin D light chain |
抗原表位 |
101-200/412 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Tissue |
Expressed in the aorta extrcellular space (at protein level). |
SIMILARITY |
Belongs to the peptidase A1 family. |
Function |
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. |
Post-translational |
N- and O-glycosylated. |
DISEASE |
Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10); also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid l |
SWISS |
P07339 |
Gene ID |
1509 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease. |