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货号 | bs-0447R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-Thyroid peroxidase antibody |
中文名称 | Rabbit Anti-Thyroid peroxidase antibody |
研究领域 | 肿瘤,细胞生物,免疫学,神经生物学,信号转导,生长因子和激素,激酶和磷酸酶,内分泌病, |
英文别名 | MSA; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX. |
反应物种(已验证) | Human |
反应物种(预测) | Mouse,Rat |
产品应用(可推荐) | WB |
推荐稀释比例 | WB=1:500-2000, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 101 |
细胞定位 | 细胞膜,细胞外基质 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from rat Thyroid peroxidase |
抗原表位 | 351-450/914 |
抗原细胞定位 | Extracellular |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Membrane; Single-pass type I membrane protein.
Isoform 3: Cell surface. |
SIMILARITY | Belongs to the peroxidase family. XPO subfamily. Contains 1 EGF-like domain. Contains 1 Sushi (CCP/SCR) domain. |
SUBUNIT | Interacts with DUOX1, DUOX2 and CYBA. |
Function | Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). |
Post-translational | Glycosylated.
Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface. Cleaved in its N-terminal part. |
DISEASE | Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]. A disorder due to defective conversion of accumulated iodide to organically bound io |
SWISS | P35419 |
Gene ID | 7173 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]. |