货号 |
bs-1517R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-NEUROD1 antibody |
中文名称 |
Rabbit Anti-NEUROD1 antibody |
研究领域 |
肿瘤,心血管,免疫学,染色质和核信号,神经生物学,干细胞,新陈代谢,表观遗传学, |
英文别名 |
atonal; Neurod1 protein; basic helix loop helix transcription factor; bHLHa3; class A basic helix loop helix protein 3; Class A basic helix-loop-helix protein 3; MODY 6; MODY6; NDF1_HUMAN; NeuroD1; neurogenic helix loop helix protein NEUROD; Beta cell E b |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Dog,Pig,Cow |
产品应用(已验证) |
WB,FCM |
产品应用(可推荐) |
IHC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=0.2ug/test,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
40 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human NEUROD1 |
抗原表位 |
21-120/356 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. Note=Inpancreatic islet cells, shuttles to the nucleus in response toglucose stimulation. Colocalizes with NR0B2 in thenucleus. |
SIMILARITY |
Contains 1 bHLH (basic helix-loop-helix) domain. |
SUBUNIT |
Interacts (via helix-loop-helix motif domain) with EP300(via C-terminus) (By similarity). Heterodimer with TCF3/E47; theheterodimer is inhibited in presence of ID2, but not NR0B2, toE-box element. Efficient DNA-binding requires dimerization withanother bH |
Function |
Acts as a transcriptional activator: mediatestranscriptional activation by binding to E box-containing promoterconsensus core sequences 5'-CANNTG-3'. Associates with the p300/CBPtranscription coactivator complex to stimulate transcription of thesecretin g |
Post-translational |
Phosphorylated. In islet cells, phosphorylated on Ser-274upon glucose stimulation; which may be required for nuclearlocalization. In activated neurons, phosphorylated on Ser-335;which promotes dendritic growth. Phosphorylated by MAPK1;phosphorylation regu |
DISEASE |
Maturity-onset diabetes of the young 6 (MODY6)[MIM:606394]: A form of diabetes that is characterized by anautosomal dominant mode of inheritance, onset in childhood or earlyadulthood (usually before 25 years of age), a primary defect ininsulin secretion a |
SWISS |
Q13562 |
Gene ID |
4760 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008] |