货号 |
bs-0826R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-TTF1 antibody |
中文名称 |
Rabbit Anti-TTF1 antibody |
研究领域 |
肿瘤,细胞生物,转录调节因子,表观遗传学, |
英文别名 |
AV026640;
BCH;
Benign chorea;
BHC;
Homeobox protein NK 2 homolog A;
Homeobox protein NK-2 homolog A;
Homeobox protein Nkx 2.1;
Homeobox protein Nkx-2.1;
Homeobox protein Nkx2.1;
NK 2;
NK 2 homolog A;
NK2;
NK2 homeobox 1;
NK2, drosophila, homo |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC,ICC,IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
38 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human TTF-1 |
抗原表位 |
201-300/372 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. |
Tissue |
Thyroid and lung. |
SIMILARITY |
Belongs to the NK-2 homeobox family.
Contains 1 homeobox DNA-binding domain. |
Function |
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development |
Post-translational |
Phosphorylated on serine residues by STK3. |
DISEASE |
Chorea, hereditary benign (BHC) [MIM:118700]: A rare autosomal dominant movement disorder, defined by early onset in childhood, a stable or non-progressive course of chorea, and no mental deterioration. Chorea is characterized by involuntary, forcible, ra |
SWISS |
P43699 |
Gene ID |
7080 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Apr 2011] |