货号 |
bsm-2000M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-HBcAg antibody |
中文名称 |
Mouse Anti-HBcAg antibody |
研究领域 |
免疫学,细菌及病毒, |
英文别名 |
C; core; E; PC; pre-C; pre-C/C; PreC; PreC/C; precore-core; Capsid protein; Core and e antigen; Core antigen; Core protein; HBc; HBVgp4; Hepatitis B Virus core antigen; p21.5; precore/core protein; Q89714_HBV. |
反应物种(预测) |
HBV |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
单克隆 |
克隆号 |
1H8 |
抗体来源 |
Mouse |
理论分子量 |
21 |
性状 |
Liquid |
免疫原 |
Recombinded human hepatitis B core antigen protein |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Capsid protein: Virion. Host cytoplasm. |
SIMILARITY |
Belongs to the orthohepadnavirus core antigen family. |
SUBUNIT |
Homodimerizes, then multimerizes. Interacts with cytosolexposed regions of viral L glycoprotein present in thereticulum-to-Golgi compartment. Interacts with human FLNB. |
Function |
Self assembles to form an icosahedral capsid. Mostcapsid appear to be large particles with a icosahedral symmetry ofT=4 and consist of 240 copies of capsid protein, though a fractionforms smaller T=3 particles consisting of 180 capsid proteins.Entering ca |
Post-translational |
Phosphorylated by host SRPK1, SRPK2, and maybe protein kinaseC or GAPDH. Phosphorylation is critical for pregenomic RNApackaging. Protein kinase C phosphorylation is stimulated by HBxprotein and may play a role in transport of the viral genome to thenucle |
SWISS |
Q89714 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection.
The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection. |