货号 |
bs-1404R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-IRF1 antibody |
中文名称 |
Rabbit Anti-IRF1 antibody |
研究领域 |
肿瘤,细胞生物,细胞凋亡,转录调节因子,细胞分化, |
英文别名 |
interferon regulatory factor 1; IRF 1; MAR1; IRF1_HUMAN. |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Dog,Pig,Cow,Sheep |
产品应用(已验证) |
WB,IHC,FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,Flow Cyt=1ug/Test, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
37 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human IRF-1 |
抗原表位 |
101-225/325 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1. |
SIMILARITY |
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain. |
SUBUNIT |
Monomer. Homodimer. Interacts with MYD88 and PIAS3 (By similarity). Interacts with EP300. |
Function |
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expr |
Post-translational |
Phosphorylated by CK2 and this positively regulates its activity. Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Ma |
DISEASE |
Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of th |
SWISS |
P10914 |
Gene ID |
3659 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression. |