货号 |
bs-0992R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-HPV16 E7 antibody |
中文名称 |
Rabbit Anti-HPV16 E7 antibody |
研究领域 |
肿瘤,免疫学,细菌及病毒, |
英文别名 |
E7; HPV16 E7 protein; Human Papilloma Virus; Human papillomavirus type 16 E7; Human papillomavirus type 16 E7; Protein E7; Human Papillomavirus 16 (E7); HPV16 E7; E7 protein (HPV16); VE7_HPV16; HPV16-E7. |
反应物种(已验证) |
Human |
反应物种(预测) |
HPV16 |
产品应用(已验证) |
FCM |
产品应用(可推荐) |
IHC |
推荐稀释比例 |
IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1ug/Test, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
11 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from the middle of HPV16-E7 |
抗原表位 |
21-98/98 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SIMILARITY |
Belongs to the papillomaviridae E7 protein family. |
SUBUNIT |
Homodimer. Homooligomer. Interaction with host RB1 induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting RB1's activity. Binds to CHD3 through its zinc-finger domain. Forms a complex with CHD3 and HDAC1, thereby altering the action of h |
Function |
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent |
SWISS |
P03129 |
Gene ID |
1489079 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. |