货号 |
bs-2127R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-5HT4 Receptor antibody |
中文名称 |
Rabbit Anti-5HT4 Receptor antibody |
研究领域 |
神经生物学,信号转导,通道蛋白,细胞膜受体,转运蛋白, |
英文别名 |
5-HTR4 (5-hydroxytryptamine (serotonin) receptor 4a); Htr4a; 5-HT4; 5-HT4A; 5HT4; Htr45 HT 4; 5 HT4; 5 HT4R; 5 hydroxytryptamine 4 receptor; 5 hydroxytryptamine receptor 4; 5 hydroxytryptamine serotonin receptor 4; 5 hydroxytryptamine4 receptor; 5HT4; 5HT |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Chicken,Cow |
产品应用(已验证) |
WB,IHC,IF |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:200-800, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
43 |
细胞定位 |
细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human 5-HTR4 |
抗原表位 |
21-120/388 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. |
Tissue |
soform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. |
SIMILARITY |
Belongs to the G-protein coupled receptor 1 family. |
SUBUNIT |
Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with INADL, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR. |
Function |
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase |
SWISS |
Q13639 |
Gene ID |
3360 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010] |