货号 |
bs-3899R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-CYP24A1 antibody |
中文名称 |
Rabbit Anti-CYP24A1 antibody |
研究领域 |
肿瘤,心血管,细胞生物,免疫学,信号转导,生长因子和激素,内分泌病,脂蛋白,新陈代谢,线抗体, |
英文别名 |
1 25 dihydroxyvitamin D3 24 hydroxylase; 1 25 dihydroxyvitamin D(3) 24 hydroxylase; 1; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24 ohase; 24-OHase; 25-dihydroxyvitamin D(3) 24-hydroxylase; CP 24; CP24; CP24A_HUMAN; CYP 24; CYP24; CYP24A1; |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit |
产品应用(已验证) |
IHC,ICC |
产品应用(可推荐) |
IF,ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
55 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human CYP24A1 |
抗原表位 |
351-450/514 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Mitochondrion. |
SIMILARITY |
Belongs to the cytochrome P450 family. |
Function |
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol lea |
DISEASE |
Hypercalcemia infantile (HCAI) [MIM:143880]: A disorder characterized by abnormally high level of calcium in the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis. Note=The disease is caused by mutations affecting the gene represented |
SWISS |
Q07973 |
Gene ID |
1591 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
CYP24A1 (cytochrome P450, family 24, subfamily A, polypeptide 1) is a member of the cytochrome P450 superfamily. It is a mitochondrial enzyme responsible for inactivating vitamin D3 metabolites through the C-24 oxidation pathway. In regulating the level of vitamin D3, CYP24A1 plays a role in calcium homeostasis and the vitamin D endocrine system. CYP24A1 also has a role in maintaining calcium homeostasis. It catalyzes the NADPH-dependent 24-hydroxylation of 25-hydroxyvitamin D(3) in the presence of adrenodoxin and NADPH-adrenodoxin reductase. |