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货号 | bs-6697R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-DICER1 antibody |
中文名称 | Rabbit Anti-DICER1 antibody |
研究领域 | 细胞生物,信号转导,表观遗传学, |
英文别名 | DCR1c; Dcr1 homolog (Drosophila)DCR1; Dcr1 homolog (Drosophila); Dicer 1; Dicer 1 ribonuclease type III; Dicer; DICER_HUMANv Dicer1v Endoribonuclease Dicer; Helicase moiv; Helicase with RNAse motif; HERNA. |
反应物种(已验证) | Human |
反应物种(预测) | Mouse,Rat,Pig,Cow,Horse |
产品应用(已验证) | ICC |
产品应用(可推荐) | WB,IHC,IF,ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000,IHC-F=1:100-500,IF=1:100-500,ICC=1:100, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 217 |
细胞定位 | 细胞浆 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from human DICER1/Dicer |
抗原表位 | 1301-1400/1922 |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Cytoplasm. |
SIMILARITY | Belongs to the helicase family. Dicer subfamily. Contains 1 Dicer dsRNA-binding fold domain. Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains |
SUBUNIT | Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, EIF2C1, PIWIL1 and PRKRA. As |
Function | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 |
DISEASE | Defects in DICER1 are a cause of pleuropulmonary blastoma (PPB) [MIM:601200]. PPB is a rare pediatric tumor of the lung that arises during fetal lung development and is often part of an inherited cancer syndrome. PPBs contain both epithelial and mesenchym |
SWISS | Q9UPY3 |
Gene ID | 23405 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] |