货号 |
bs-3027R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-AMPK beta 1 + AMPK beta 2 (Ser182/Ser184) antibody |
中文名称 |
Rabbit Anti-phospho-AMPK beta 1 + AMPK beta 2 (Ser182/Ser184) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
肿瘤,细胞生物,信号转导,细胞凋亡,转录调节因子,激酶和磷酸酶 |
英文别名 |
phospho-AMPK beta 1 + AMPK beta 2 (Ser182+Ser184); PRKAB1(phospho S182); PRKAB1(phospho-S182); AMPK beta 1(phospho Ser182); p-AMPK beta 1(Ser182); p-AMPK beta 1(S182); AMPK beta 2(phospho Ser184); 5 AMP activated protein kinase subunit beta 1; AMPK; AMPK |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Dog,Cow,Horse,Rabbit |
产品应用(已验证) |
IHC,FCM |
产品应用(可推荐) |
WB,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=2ug/Test,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
30 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthesised phosphopeptide derived from human AMPK beta 1 around the phosphorylation site of Ser182 |
抗原表位 |
SS(p-S)PP |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
Tissue |
Highly expressed in kidney, heart, white adipose tissue, lung and spleen. |
SIMILARITY |
Belongs to the 5'-AMP-activated protein kinase beta subunit family. |
SUBUNIT |
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. |
Function |
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways an |
Post-translational |
Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. |
SWISS |
Q9Y478 |
Gene ID |
5564 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]. |