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货号 | bs-1707R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-Angiotensin I antibody |
中文名称 | Rabbit Anti-Angiotensin I antibody |
研究领域 | 肿瘤,心血管,细胞生物,生长因子和激素,新陈代谢, |
英文别名 | AGT; Alpha 1 antiproteinase antitrypsin; Ang I; Ang II; Ang III; Angiotensin 1; Angiotensin; Angiotensin I; Angiotensin II; Angiotensin-2; Angiotensin III; Angiotensin-3; Angiotensinogen; Angiotensinogen serpin peptidase inhibitor clade A member 8; ANGT_H |
反应物种(已验证) | Mouse |
反应物种(预测) | Human,Rat,Dog,Horse,Sheep |
产品应用(已验证) | WB |
产品应用(可推荐) | IHC,IF,ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 50 |
细胞定位 | 分泌型蛋白 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide of human Angiotensin I(C-DRVYIHPFHL) |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Secreted. |
Tissue | Expressed by the liver and secreted in plasma. |
SIMILARITY | Belongs to the serpin family. |
SUBUNIT | During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg. |
Function | Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility a |
Post-translational | Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor. In response |
DISEASE | Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Renal |
SWISS | P01019 |
Gene ID | 183 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
CAS | 3 |
英文介绍 | The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. active peptide sequence:DRVYIHPFHL |