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货号 | bs-3468R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-phospho-VEGFR2 (Tyr1175) antibody |
中文名称 | Rabbit Anti-phospho-VEGFR2 (Tyr1175) antibody |
产品标签 | 磷酸化抗体 |
研究领域 | 肿瘤,心血管,细胞生物,免疫学,信号转导,生长因子和激素,转录调节因子,激酶和磷酸酶,血管内皮细胞, |
英文别名 | VEGFR2(Phospho-Tyr1175); VEGFR2(Phospho-Y1175); p-VEGFR2(Tyr1175); p-VEGFR2(Y1175); CD309; CD309 antigen; Fetal liver kinase 1; FLK-1; FLK1; KDR; Kinase insert domain receptor (a type III receptor tyrosine kinase); Kinase insert domain receptor; KRD1; Ly7 |
反应物种(已验证) | Mouse,Rat |
反应物种(预测) | Dog,Pig,Cow,Horse,Rabbit |
产品应用(已验证) | WB,FCM |
产品应用(可推荐) | ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000,Flow Cyt=2ug/test, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 147 |
细胞定位 | 细胞核,细胞浆,细胞膜,分泌型蛋白 |
性状 | Liquid |
免疫原 | KLH conjugated Synthesised phosphopeptide derived from human VEGFR2 around the phosphorylation site of Tyr1175 |
抗原表位 | KD(p-Y)IV |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. P |
Tissue | Detected in cornea (at protein level). Widely expressed. |
SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain. |
SUBUNIT | Interacts with MYOF (By similarity). Interacts with VEGFA, VEGFC and VEGFD. Monomer in the absence of bound VEGFA, VEGFC or VEGFD. Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD. Can also form heterodimers with FLT1 and FLT4. Interacts ( |
Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival |
Post-translational | N-glycosylated.
Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its degradation via the proteasome or lysosomal proteases. Autophosphorylated on tyrosine residues upon ligand binding. Autophosph |
DISEASE | Defects in KDR are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, o |
SWISS | P35968 |
Gene ID | 3791 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]. |