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货号 | bs-5591R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-phospho-YES1 (Tyr426) antibody |
中文名称 | Rabbit Anti-phospho-YES1 (Tyr426) antibody |
产品标签 | 磷酸化抗体 |
研究领域 | 肿瘤,免疫学,信号转导,激酶和磷酸酶 |
英文别名 | YES1(phospho Y426); c Yes; c-Yes; Cellular Yes 1 protein; Cellular Yes1 protein; HsT441; P61 YES; p61-Yes; Proto oncogene tyrosine protein kinase YES; Proto-oncogene c-Yes; Proto-oncogene tyrosine-protein kinase Yes; v yes 1 Yamaguchi sarcoma viral oncoge |
反应物种(已验证) | Human,Mouse,Rat |
反应物种(预测) | Chicken,Dog,Pig,Cow,Rabbit,GuineaPig |
产品应用(已验证) | WB |
产品应用(可推荐) | ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 60 |
细胞定位 | 细胞浆,细胞膜 |
性状 | Liquid |
免疫原 | KLH conjugated Synthesised phosphopeptide derived from human YES1 around the phosphorylation site of Tyr426 |
抗原表位 | NE(p-Y)TA |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Cell membrane. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. |
Tissue | Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes i |
SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain. |
SUBUNIT | Interacts with YAP1 and CSF1R. Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1. Interacts with FASLG. |
Function | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R |
Post-translational | Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.
Palmitoylation at Cys-3 promotes membrane localization . |
SWISS | P07947 |
Gene ID | 7525 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq]. |