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货号 | bs-10271R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-phospho-VAV3 (Tyr141) antibody |
中文名称 | Rabbit Anti-phospho-VAV3 (Tyr141) antibody |
产品标签 | 磷酸化抗体 |
研究领域 | 肿瘤,免疫学,信号转导,转录调节因子,G蛋白偶联受体, |
英文别名 | VAV3(phospho Tyr141); VAV3(phospho Y141); Guanine nucleotide exchange factor VAV3; Protein vav 3; Protein vav3; VAV 3; Vav 3 guanine nucleotide exchange factor; VAV 3 oncogene; VAV 3 protein; VAV-3; VAV3 oncogene; VAV3 protein; VAV3_HUMAN. |
反应物种(已验证) | Mouse,Rat |
反应物种(预测) | Human,Cow,Horse,Sheep |
产品应用(已验证) | WB |
产品应用(可推荐) | IHC,ICC,IF,ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 93 |
细胞定位 | 细胞浆,细胞外基质 |
性状 | Liquid |
免疫原 | KLH conjugated Synthesised phosphopeptide derived from human VAV3 around the phosphorylation site of Tyr141 |
抗原表位 | DI(p-Y)KG |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
Tissue | Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, f |
SIMILARITY | Contains 1 CH (calponin-homology) domain. Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 SH2 domain. Contains 2 SH3 domains. |
SUBUNIT | Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation. |
Function | Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-ind |
SWISS | Q9UKW4 |
Gene ID | 10451 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge; Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis. |