货号 |
bs-9734R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-TSSK6 antibody |
中文名称 |
Rabbit Anti-TSSK6 antibody |
研究领域 |
肿瘤,细胞生物,发育生物学,信号转导,细胞周期蛋白,细胞分化,表观遗传学, |
英文别名 |
Cancer/testis antigen 72; CT72; EC 2.7.11.1; Serine/threonine-protein kinase SSTK; Small serine/threonine kinase; Small serine/threonine protein kinase; SSTK; testis-specific serine kinase 6; Testis-specific serine/threonine kinase 6; Testis-specific seri |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Dog,Cow,Rabbit,Sheep |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
WB,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
30 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human TSSK6/CT72 |
抗原表位 |
1-100/273 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
Tissue |
Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes. |
SIMILARITY |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 protein kinase domain. |
SUBUNIT |
Interacts with the heatshock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity. |
Function |
Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). |
Post-translational |
Autophosphorylated. |
SWISS |
Q9BXA6 |
Gene ID |
83983 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility. |