货号 |
bs-13202R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-FOXH1 antibody |
中文名称 |
Rabbit Anti-FOXH1 antibody |
研究领域 |
肿瘤,细胞生物,发育生物学,信号转导,转录调节因子,细胞分化,表观遗传学, |
英文别名 |
FAST 1; Fast 2; Fast-1; Fast-2; FAST1; Fast2; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2; Forkhead box H1; Forkhead box protein H1; FOX H1; FOXH 1; FOXH1; FOXH1_HUMAN; hFAST 1; hFAST-1; hFAST1; Human homolog of Xenopus fork |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Pig,Cow,Horse,Sheep |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
39 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human FOXH1 |
抗原表位 |
41-140/365 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. |
Tissue |
Ubiquitous. |
SIMILARITY |
Contains 1 fork-head DNA-binding domain. |
SUBUNIT |
Interacts with the MH2 domains of SMAD2 and SMAD3. |
Function |
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a s |
SWISS |
O75593 |
Gene ID |
8928 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Xenopus winged-helix factor, xFAST-1 (forkhead activin signal transducer-1) is a transcription factor that forms a complex with the receptor-regulated Smad protein, Smad2, and directly binds to activin response elements on DNA (1,2). The human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states (3,4). FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4 (3,5). Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues (6,7). FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFG?and activin, indicating that these FAST proteins mediate TFG?induced signal transduction (3). |