货号 |
bs-18107R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-HUS1 antibody |
中文名称 |
Rabbit Anti-HUS1 antibody |
研究领域 |
细胞生物,转录调节因子,表观遗传学, |
英文别名 |
Checkpoint protein HUS1;
hHUS1;
HUS1 (S. pombe) checkpoint homolog;
Hus1;
HUS1 checkpoint homolog (S. pombe);
HUS1 Checkpoint Protein;
HUS1 protein;
HUS1+ - like protein;
HUS1_HUMAN;
Hydroxyurea-sensitive 1, S. pombe, homolog of. |
反应物种(已验证) |
Rat |
反应物种(预测) |
Human,Mouse,Pig,Cow,Horse |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
ICC,IF,ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
32 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human HUS1 |
抗原表位 |
51-150/280 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Cytoplasm. In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm. |
Tissue |
Ubiquitous. |
SIMILARITY |
Belongs to the HUS1 family. |
Function |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platfo |
SWISS |
O60921 |
Gene ID |
3364 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011] |