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货号 | bs-7685R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-Corin antibody |
中文名称 | Rabbit Anti-Corin antibody |
研究领域 | 心血管,细胞生物,激酶和磷酸酶 |
英文别名 | ATC 2; ATC2; Atrial natriuteric peptide converting enzyme; Corin serine peptidase; CRN; Heart specific serine proteinase; Heart specific serine proteinase ATC2; Lrp 4 ; Lrp4; Pro ANP convertase; Pro ANP converting enzyme; TMPRSS 10; Transmembrane protease |
反应物种(已验证) | Human,Rat |
反应物种(预测) | Mouse,Dog,Pig,Horse |
产品应用(已验证) | FCM |
产品应用(可推荐) | IHC,IF,ELISA |
推荐稀释比例 | Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1ug/Test,IF=1:100-500, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 115 |
细胞定位 | 细胞膜,分泌型蛋白 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from human Corin |
抗原表位 | 165-245/1042 |
抗原细胞定位 | Extracellular |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Cell membrane; Single-pass type II membrane protein. Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble f |
Tissue | Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. |
SIMILARITY | Belongs to the peptidase S1 family. Contains 2 FZ (frizzled) domains. Contains 7 LDL-receptor class A domains. Contains 1 peptidase S1 domain. Contains 1 SRCR domain. |
Function | Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriure |
Post-translational | N-glycosylated; required for processing and activation. |
SWISS | Q9Y5Q5 |
Gene ID | 10699 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | Corin was first described as a trypsin-like serine proteinase in the heart which processed pro-atrial natriuretic peptide into the active form ANP. Corin cleaves pro-ANP at Arg98/Ser-99, and blocking Corin message inhibits pro-ANP processing. Null mutant mice lacking Corin develop hypertension, and a series of missense mutations have been identified in humans with high blood pressure and hypertension. Corin is a member of the type-II transmembrane serine proteinases, such as Hepsin, Epitheliasin, Matriptase and enteropeptidase. The Corin domain structure includes a cytoplasmic domain, a transmembrane domain, a spacer region, a frizzled-like domain, 5 LDL Receptor-like domains, another frizzled-like domain, 3 more LDLR-like repeats, a SRCR (Scavenger Receptor-Cysteine Rich) domain (also called macrophage scavenger-like domain), and finally the trypsin-like serine proteinase domain. The complex domain structure puts Corin into the “mosaic” TMPRSS family, so named because of the wide variety of domains. |