货号 |
bs-8491R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-FBXO25 antibody |
中文名称 |
Rabbit Anti-FBXO25 antibody |
研究领域 |
细胞生物,免疫学,信号转导,转录调节因子,表观遗传学, |
英文别名 |
F box only protein 25; F box protein 25; F box protein Fbx25; F-box only protein 25; FBX25; MGC20256; MGC51975; OTTHUMP00000115399; |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Pig,Rabbit |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
43 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human FBXO25 |
抗原表位 |
55-150/367 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nuclear. Note=In the nucleus, associateswith a subnuclear dot-like structure. Colocalized with SKP1 |
Tissue |
Expressed in all brain tissue observed. |
SIMILARITY |
Contains 1 F-box domain. |
SUBUNIT |
Part of a SCF (SKP1-cullin-F-box) protein ligase complexconsisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly withSKP1 and CUL1. Interacts (via C-terminus) with beta-actin (viaN-terminus). |
Function |
Substrate-recognition component of the SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mayplay a role in accumulation of expanded polyglutamine (polyQ)protein huntingtin (HTT) (By similarity). |
DISEASE |
Note=A chromosomal aberration involving FBXO25 is a causeof X-linked mental retardation (XLMR). Translocationt(X;8)(p11.22;p23.3) with SHROOM4. |
SWISS |
Q8TCJ0 |
Gene ID |
26260 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
FBXO25 is a member of the F box protein family which is characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1 cullin F box), which function in phosphorylation dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD 40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein protein interaction modules or no recognizable motifs. FBXO25 belongs to the Fbxs class. There are three named isoforms produced by alternative splicing.
FBXO25, also known as FBX25, is a 367 amino acid protein that contains one C-terminal F-box domain and belongs to the Fbx class of the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Expressed at high levels in brain, FBXO25 localizes predominantly to the nucleus and directly interacts with Skp1 p19 and CUL-1. Disruption of the gene encoding FBXO25 can lead to X-linked mental retardation. |