货号 |
bs-5335R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Phospho-ELk1 (Ser389) antibody |
中文名称 |
Rabbit Anti-Phospho-ELk1 (Ser389) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
肿瘤,生长因子和激素,转录调节因子 |
英文别名 |
Elk-1(Phospho-Ser389); ELK1 (phospho S389); p-ELK1 (phospho S389); ELK 1; ELK1 member of ETS oncogene family; ELK1 protein; ELK2 member of ETS oncogene family; ETS domain containing protein Elk 1; ETS domain containing protein Elk1; ETS domain protein Elk |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,GuineaPig |
产品应用(可推荐) |
WB,IHC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
47 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human ELk1 around the phosphorylation site of Ser389 |
抗原表位 |
PR(p-S)PA |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. |
Tissue |
Lung and testis. |
SIMILARITY |
Belongs to the ETS family. Contains 1 ETS DNA-binding domain. |
SUBUNIT |
Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9. |
Function |
Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element. |
Post-translational |
Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
On mitogenic |
SWISS |
P19419 |
Gene ID |
2002 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]. |