货号 |
bs-5475R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-MBP (Tyr203) antibody |
中文名称 |
Rabbit Anti-phospho-MBP (Tyr203) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
免疫学,神经生物学,信号转导,转录调节因子 |
英文别名 |
MBP(phospho Tyr203); MBP(phospho Y203); Myelin basic protien; GDB; Golli MBP; Hemopoietic MBP; HMBPR; HUGO; MBP; MGC99675; MLD; Myelin A1 Protein; Myelin Deficient; Myelin Membrane Encephalitogenic Protein; SHI; Shiverer; SP. |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Dog |
产品应用(已验证) |
FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,Flow Cyt=1ug/Test, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
33 |
细胞定位 |
细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human MBP around the phosphorylation site of Tyr203 |
抗原表位 |
AH(p-Y)GS |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin. |
Tissue |
MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. |
SIMILARITY |
Belongs to the myelin basic protein family. |
SUBUNIT |
Homodimer. Isoform 3 exists as a homodimer. |
Function |
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in re |
Post-translational |
Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or |
SWISS |
P02686 |
Gene ID |
4155 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Oligodendrocyte Marker
The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function. |