货号 |
bs-2895R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-HDAC1 antibody |
中文名称 |
Rabbit Anti-HDAC1 antibody |
研究领域 |
肿瘤,免疫学,信号转导,细胞凋亡,转录调节因子 |
英文别名 |
HD 1; HD1; HDAC 1; hdac1: histone deacetylase 1; Histone deacetylase 1 (HD1); Histone deacetylase 1; RPD3 (reduced potassium dependency yeast homolog) like 1; RPD3 (reduced potassium dependency); RPD3; RPD3L1; DKFZp686H12203; GON 10. HDAC1_HUMAN |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Dog,Pig,Cow,Sheep,GuineaPig |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
WB,IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
55 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human HDAC1 |
抗原表位 |
401-482/482 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. |
Tissue |
Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain. |
SIMILARITY |
Belongs to the histone deacetylase family. HD type 1 subfamily. |
Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progr |
Post-translational |
Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.
Ubiquitinated by |
SWISS |
Q13547 |
Gene ID |
3065 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008] |