货号 |
bs-5246R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-Cdc6 (Ser54) antibody |
中文名称 |
Rabbit Anti-phospho-Cdc6 (Ser54) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
细胞生物,染色质和核信号,细胞周期蛋白,转录调节因子,细胞分化, |
英文别名 |
Cell Division Cycle protein 6; Cdc 18L; Cdc 6; CDC18 (cell division cycle 18, S.pombe, homolog) like; CDC18 (S.pombe); CDC18 like; CDC18(S.pombe); Cdc18L; CDC6 related protein; Cdc6p; Cell cycle controller; Cell division control protein 6; Cell division c |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Dog,Pig,Horse,Rabbit,Sheep |
产品应用(已验证) |
ICC |
产品应用(可推荐) |
WB,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
63 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human Cdc6 around the phosphorylation site of Ser54 |
抗原表位 |
PL(p-S)PR |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells. |
SIMILARITY |
Belongs to the CDC6/cdc18 family. |
SUBUNIT |
Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. |
Function |
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
DISEASE |
Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:613805]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature |
SWISS |
Q99741 |
Gene ID |
990 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. |