货号 |
bs-10608R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-MCM2 (Ser53) antibody |
中文名称 |
Rabbit Anti-phospho-MCM2 (Ser53) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
细胞生物,染色质和核信号,表观遗传学, |
英文别名 |
MCM4 (phospho S53); MCM2(phospho-Ser53); MCM2(phospho Ser53); MCM2 (phospho S54); p-MCM2(Ser53); p-MCM2(S53); rat MCM4 (phospho S54); BM28; CCNL 1; CCNL1; CDC like 1; CDC like-1; cdc19; CDCL 1; CDCL1; Cell devision cycle like 1; Cyclin like 1; cyclin like |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Chicken,Dog,Pig,Horse,Rabbit,Zebrafish,Sheep |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
101 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human MCM2 around the phosphorylation site of Ser53 |
抗原表位 |
DE(p-S)EG |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus (Probable). |
SIMILARITY |
Belongs to the MCM family. Contains 1 MCM domain. |
SUBUNIT |
Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Interacts with KAT7 and DBF4. May interact with MCM10. |
Function |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed throu |
Post-translational |
Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Phosphor |
SWISS |
P49736 |
Gene ID |
4171 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012] |