货号 |
bs-17137R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-SP1 (Thr739) antibody |
中文名称 |
Rabbit Anti-phospho-SP1 (Thr739) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
细胞生物,染色质和核信号,干细胞,转录调节因子,锌指蛋白,表观遗传学, |
英文别名 |
SP1 (phospho T739); SP1 (phospho-Thr739); SP1 (phospho-T739); p-SP1 (phospho T453); p-TSFP1 (phospho T453); Sp1 transcription factor isoform a; TSFP1; TSFP 1; Specificity protein 1; Transcription factor Sp1; SP1_HUMAN. |
反应物种(已验证) |
Human |
反应物种(预测) |
Cow,Horse,African Green Monkey |
产品应用(已验证) |
ICC |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
81 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthesised phosphopeptide derived from human SP1 around the phosphorylation site of Thr739 |
抗原表位 |
TA(p-T)PS |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Cytoplasm. Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location. |
Tissue |
Up-regulated in adenocarcinomas of the stomach (at protein level). |
SIMILARITY |
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers. |
Function |
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes su |
DISEASE |
Phosphorylated on multiple serine and threonine residues. Phosphorylation is coupled to ubiquitination, sumoylation and proteolytic processing. Phosphorylation on Ser-59 enhances proteolytic cleavage. Phosphorylation on Ser-7 enhances ubiquitination a |
SWISS |
P08047 |
Gene ID |
6667 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |