货号 |
bs-19654R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-OLIG2 (Ser10+Ser13+Ser14) antibody |
中文名称 |
Rabbit Anti-phospho-OLIG2 (Ser10+Ser13+Ser14) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
神经生物学,干细胞,表观遗传学, |
英文别名 |
Olig2 (phospho S10 + S13 + S14); p-Olig2 (phospho S10 + S13 + S14);
Basic domain helix loop helix protein class B 1;
Basic helix loop helix protein class B 1;
BHLHB;
bHLHB1;
bHLHe19;
Class B basic helix loop helix protein 1;
Class B basic helix-loop |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Chicken,Cow |
产品应用(已验证) |
FCM |
产品应用(可推荐) |
WB,IHC,IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1ug/Test,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
32 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthesised phosphopeptide derived from human OLIG2 around the phosphorylation site of Ser10+Ser13+Ser14 |
抗原表位 |
VS(p-S)RP(p-S)(p-S)PE |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. |
Tissue |
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
SIMILARITY |
Contains 1 basic helix-loop-helix (bHLH) domain. |
Function |
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 inte |
DISEASE |
Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. |
SWISS |
Q13516 |
Gene ID |
10215 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008] |