货号 |
bs-20496R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Tubulin alpha (Loading Control) antibody |
中文名称 |
Rabbit Anti-Tubulin alpha (Loading Control) antibody |
产品标签 |
内参抗体 |
研究领域 |
细胞生物,免疫学,细胞骨架, |
英文别名 |
TUBA1A + TUBA1B;
Tubulin, Alpha 1b;
Tubulin Alpha-Ubiquitous Chain;
Alpha-Tubulin Ubiquitous;
Tubulin K-Alpha-1;
Tubulin, Alpha, Ubiquitous;
Tubulin Alpha-1B Chain;
Alpha Tubulin;
Tubulin-alpha;
Ubiquitous;
K-ALPHA-1;
Tubulin Alpha;
TBA1B_HUM |
中文别名 |
微管蛋白alpha |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Chicken,Pig,Cow |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
50 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human TUBA1A + TUBA1B |
抗原表位 |
401-451/451 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm, cytoskeleton. |
Tissue |
Ubiquitously expressed with highest levels in Brain, Bone, Adipocyte, and Breast |
SIMILARITY |
Belongs to the tubulin family. |
SUBUNIT |
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtub |
Function |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain |
Post-translational |
Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
Some glutamate residues at the |
SWISS |
Q71U36 |
Gene ID |
7846 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] |