货号 |
bsm-33061M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-Cytokeratin 8 antibody |
中文名称 |
Mouse Anti-Cytokeratin 8 antibody |
研究领域 |
肿瘤,细胞生物,信号转导 |
英文别名 |
card2; Cardiac autoantigen 2 120kD; CK 8; CK8; CK-8; ck8; Cyk 8; cyk8; CYKER; Cytokeratin endo A; Cytokeratin-8; Cytokeratin8; DreK8; EndoA; k0; CYK8; k2c8; K2C8_HUMAN; k8; Keratin 8; Keratin type ii cytoskeletal 8; Keratin, type II cytoskeletal 8; Kerati |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
IHC,IF,FCM |
推荐稀释比例 |
IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1ug/Test,IF=1:200-800, |
克隆类型 |
单克隆 |
克隆号 |
10A8 |
抗体来源 |
Mouse |
理论分子量 |
53 |
细胞定位 |
细胞核,细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
Recombinant human CK8 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein G |
SUBCELLULAR |
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. |
Tissue |
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. |
Function |
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
Post-translational |
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decrease |
DISEASE |
Defects in KRT8 are a cause of cirrhosis (CIRRH) [MIM:215600]. |
SWISS |
P05787 |
Gene ID |
3856 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]. |