货号 |
bsm-33062M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-CK16 antibody |
中文名称 |
Mouse Anti-CK16 antibody |
研究领域 |
肿瘤,细胞生物,免疫学,信号转导 |
英文别名 |
Cytokeratin 16; CK 16; Focal non epidermolytic palmoplantar keratoderma; K 16; K16; K1CP; CK-16; CK16; Cytokeratin-16; FNEPPK; K1C16_HUMAN; Keratin; Keratin-16; type I cytoskeletal 16; Keratin 16; Keratin type I cytoskeletal 16; Keratin16; KRT 16; KRT16; |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat |
产品应用(已验证) |
IHC,IF |
产品应用(可推荐) |
ICC |
推荐稀释比例 |
IHC-P=1:100-500,IHC-F=1:100-500,IF=1:200-800,ICC=1:100, |
克隆类型 |
单克隆 |
克隆号 |
8H6 |
抗体来源 |
Mouse |
理论分子量 |
51 |
细胞定位 |
细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
Recombinant human CK16 protein |
抗原表位 |
full length |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein G |
Tissue |
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts. |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers. Interacts with TCHP. Interacts with TRADD (By similarity). |
DISEASE |
Pachyonychia congenita 1 (PC1) [MIM:167200]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyper |
SWISS |
P08779 |
Gene ID |
3868 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]. |