货号 |
bsm-33065M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-GFAP antibody |
中文名称 |
Mouse Anti-GFAP antibody |
研究领域 |
肿瘤,细胞生物,神经生物学 |
英文别名 |
Astrocyte; FLJ45472; GFAP; Glial Fibrillary Acidic Protein; Intermediate filament protein; GFAP_HUMAN. |
反应物种(已验证) |
Mouse,Rat |
产品应用(已验证) |
WB,IHC,ICC |
推荐稀释比例 |
WB=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500, |
克隆类型 |
单克隆 |
克隆号 |
7D8 |
抗体来源 |
Mouse |
理论分子量 |
49 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
Recombinant mouse GFAP full length |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein G |
SUBCELLULAR |
Cytoplasm. Note=Associated with intermediate filaments. |
Tissue |
Expressed in cells lacking fibronectin. |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Interacts with SYNM. Isoform 3 interacts with PSEN1 (via N-terminus). |
Function |
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
Post-translational |
Phosphorylated by PKN1. |
DISEASE |
Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are |
SWISS |
P14136 |
Gene ID |
2670 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |