货号 |
bsm-33375M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-HP1 gamma antibody |
中文名称 |
Mouse Anti-HP1 gamma antibody |
研究领域 |
肿瘤,细胞生物,染色质和核信号 |
英文别名 |
CBX 3; CBX3; Chromobox homolog 3; Chromobox protein homolog 3; HECH; Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma; Heterochromatin protein HP1 gamma; HP1 gamma homolog; HP1Hs gamma ; Modifier 2; protein HP1-GAMMA; HP1g; M32; MGC |
中文别名 |
HP-1-γ; HP 1γ; HP-1γ; HP-1 γ; HP1γ; HP1 γ; |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
ICC,IF,ELISA |
推荐稀释比例 |
Elisa=1:1000-5000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
单克隆 |
克隆号 |
5B9 |
抗体来源 |
Mouse |
理论分子量 |
21 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
Recombinant human HP1 gamma Protein |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein G |
SUBCELLULAR |
Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). |
SIMILARITY |
Contains 2 chromo domains. |
SUBUNIT |
Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, |
Function |
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuc |
Post-translational |
Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. |
SWISS |
Q13185 |
Gene ID |
11335 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |