货号 |
bsm-33040M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-Lamin B (Nuclear Loading Control) antibody |
中文名称 |
Mouse Anti-Lamin B (Nuclear Loading Control) antibody |
产品标签 |
内参抗体 |
研究领域 |
细胞生物,染色质和核信号,信号转导,细胞凋亡,细胞类型标志物(Nuclear Envelope Marker), |
英文别名 |
lamin B1; LMB1; LMN; LMN2; LMNB 1; LMNB; LMNB1; MGC111419; LMNB1_HUMAN; Lamin-B1. |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-1000,Elisa=1:5000-10000, |
克隆类型 |
单克隆 |
克隆号 |
9C11 |
抗体来源 |
Mouse |
理论分子量 |
64 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
Recombinant human Lamin B Protein |
抗原表位 |
314-386/586 |
亚型 |
IgG1 |
纯化方法 |
affinity purified by Protein G |
SUBCELLULAR |
Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Homodimer. Interacts with lamin-associated polypeptides IA, IB and 2. |
Function |
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin |
Post-translational |
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. |
DISEASE |
Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characteri |
SWISS |
P20700 |
Gene ID |
4001 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]. |