货号 |
bsm-51126M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-MUC1 antibody |
中文名称 |
Mouse Anti-MUC1 antibody |
研究领域 |
肿瘤 |
英文别名 |
KL-6; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; Breast carcinoma associated antigen DF3; CA 15 3; CA15-3; CA15-3 antigen; CA15.3; CA-153; Carcinoma associated mucin; CD 227; CD227; CD227 antigen; DF3 antigen; EMA; Episialin; Epithelial membrane antigen; Epithel |
反应物种(已验证) |
Human |
产品应用(已验证) |
WB,ICC,FCM |
推荐稀释比例 |
WB=1:100-300,Flow Cyt=1ug/Test,ICC=1:100, |
克隆类型 |
单克隆 |
克隆号 |
M5C7 |
抗体来源 |
Mouse |
理论分子量 |
20 |
细胞定位 |
细胞核,细胞浆,细胞膜,分泌型蛋白 |
性状 |
Liquid |
免疫原 |
Recombinant human MUC1 |
亚型 |
IgG2b |
纯化方法 |
affinity purified by Protein G |
SUBCELLULAR |
Apical cell membrane; Single-pass type I membrane protein. Isoform 5: Secreted. Isoform 7: Secreted. Isoform 9: Secreted. Mucin-1 subunit beta: Cell membrane. Cytoplasm. Nucleus. |
Tissue |
Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tum |
SIMILARITY |
Contains 1 SEA domain. |
SUBUNIT |
The alpha subunit forms a tight, non-covalent heterodimeric complex with the proteolytically-released beta-subunit. |
Function |
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
The beta subunit contains a C-terminal domain which is in |
Post-translational |
Highly glycosylated (N- and O-linked carbohydrates and sialic acid). O-glycosylated to a varying degree on serine and threonine residues within each tandem repeat, ranging from mono- to penta-glycosylation. The average density ranges from about 50% in hum |
SWISS |
P15941 |
Gene ID |
4582 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. |