货号 |
bsm-51065M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-CD44 antibody |
中文名称 |
Mouse Anti-CD44 antibody |
研究领域 |
肿瘤,免疫学,干细胞,细胞表面分子,糖蛋白, |
英文别名 |
LHR; BA-1; CD 44; CD44 antigen; CD44 molecule; CD44_HUMAN; CDw44; Cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and |
反应物种(已验证) |
Human |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ICC,IF |
推荐稀释比例 |
WB=1:200-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:20-200,ICC=1:100-500, |
克隆类型 |
单克隆 |
克隆号 |
10B3 |
抗体来源 |
Mouse |
理论分子量 |
85 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
Recombinant human CD44 |
亚型 |
IgG2a |
纯化方法 |
affinity purified by Protein G |
SUBCELLULAR |
Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. |
Tissue |
Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. |
SIMILARITY |
Contains 1 Link domain. |
SUBUNIT |
Interacts with PKN2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. |
Function |
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA |
Post-translational |
Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect th |
SWISS |
P16070 |
Gene ID |
960 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]. |