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货号 | bsm-41168M-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Mouse Anti-beta 2 Microglobulin (7B5) antibody |
中文名称 | Mouse Anti-beta 2 Microglobulin (7B5) antibody |
研究领域 | 免疫学,新陈代谢, |
英文别名 | B2M; Beta-2-MG; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; Beta 2 microglobin; Beta-2 microglobulin precursor; Beta chain of mhc class 1 proteins; Beta chain of MHC class I molecules; Beta-2-microglobulin for |
中文别名 | β2 Microglobulin; β2-Microglobulin; β-2-Microglobulin; bsm-41182M |
反应物种(已验证) | Human |
产品应用(已验证) | WB,IHC |
产品应用(可推荐) | ICC,IF,ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 | 单克隆 |
克隆号 | 7B5 |
抗体来源 | Mouse |
理论分子量 | 13 |
细胞定位 | 分泌型蛋白 |
性状 | Liquid |
免疫原 | Recombinant human beta 2 Microglobulin protein |
亚型 | IgG1 |
纯化方法 | affinity purified by Protein G |
SUBCELLULAR | Secreted. Note=Detected in serum and urine. |
SIMILARITY | Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain. |
SUBUNIT | Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. |
Function | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. |
Post-translational | Glycation of Ile-21 is observed in long-term hemodialysis patients. |
DISEASE | Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may |
SWISS | P61769 |
Gene ID | 567 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | bsm-41168M(capture) is Matched Pair with bsm-41182M(detection). This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009]. |