货号 |
bsm-52048R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Cyclin E1 antibody |
中文名称 |
Rabbit Anti-Cyclin E1 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
细胞生物,细胞周期蛋白 |
英文别名 |
CCNE 1; CCNE; CCNE1; Cyclin Es; Cyclin Et; CyclinE; G1/S specific cyclin E; G1/S-specific cyclin-E1; CCNE1_HUMAN; pCCNE1. |
反应物种(已验证) |
Human,Mouse |
产品应用(已验证) |
WB,IHC,ICC |
推荐稀释比例 |
WB=1:500,IHC-P=1:100-500,ICC=1:50, |
克隆类型 |
单克隆 |
克隆号 |
4H7 |
抗体来源 |
Rabbit |
理论分子量 |
45 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
Recombinant human Cyclin E1 protein(100-200aa) |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. |
Tissue |
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. |
SIMILARITY |
Belongs to the cyclin family. Cyclin E subfamily. |
SUBUNIT |
Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a compl |
Function |
Essential for the control of the cell cycle at the G1/S (start) transition. |
Post-translational |
Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR. |
SWISS |
P24864 |
Gene ID |
898 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016] |