货号 |
bsm-52157R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-GATA3 (Ser308) antibody |
中文名称 |
Rabbit Anti-phospho-GATA3 (Ser308) antibody |
产品标签 |
磷酸化抗体,重组兔单抗 |
研究领域 |
肿瘤,细胞生物,发育生物学,神经生物学,信号转导,转录调节因子,T-淋巴细胞, |
英文别名 |
GATA3 (phospho S308); p-GATA3 (phospho S308); GATA3 (phospho Ser308); p-GATA3 (Ser308); GATA 3; GATA3; GATA-3; GATA binding factor 3; GATA binding protein 3; HDR; MGC2346; MGC5199; MGC5445; Trans acting T cell specific transcription factor GATA 3; GATA3_H |
反应物种(已验证) |
Human |
产品应用(已验证) |
WB,IHC,FCM |
产品应用(可推荐) |
ICC,IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,Flow Cyt=2ug/Test,IF=1:50-200,ICC=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
3A1 |
抗体来源 |
Rabbit |
理论分子量 |
49 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthesised phosphopeptide derived from human GATA3 around the phosphorylation site of Ser308 |
抗原表位 |
RL(pS)AA |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. |
Tissue |
T-cells and endothelial cells. |
SIMILARITY |
Contains 2 GATA-type zinc fingers. |
Function |
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. |
DISEASE |
Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome. |
SWISS |
P23771 |
Gene ID |
2625 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites. |