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货号 | bsm-52015R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-A-RAF (24D1) antibody |
中文名称 | Rabbit Anti-A-RAF (24D1) antibody |
产品标签 | 重组兔单抗 |
研究领域 | 肿瘤,细胞生物,免疫学,神经生物学,信号转导,转录调节因子,激酶和磷酸酶 |
英文别名 | A raf 1; A-Raf; Raf1; A Raf proto oncogene serine/threonine protein kinase; ARAF 1; ARAF; ARaf proto oncogene serine/threonine protein kinase; ARAF1; Oncogene Araf1; Oncogene PKS2; PKS 2; PKS; PKS2; Proto oncogene Pks; RAFA 1; RAFA1; Ras binding protein |
反应物种(已验证) | Human |
产品应用(已验证) | WB |
产品应用(可推荐) | IHC,ICC,IF |
推荐稀释比例 | WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,ICC=1:50-200, |
克隆类型 | 单克隆 |
克隆号 | 24D1 |
抗体来源 | Rabbit |
理论分子量 | 68 |
细胞定位 | 细胞浆 |
性状 | Liquid |
免疫原 | Recombinant human A-RAF protein (150-300aa) |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
Tissue | Predominantly in urogenital tissues. |
SIMILARITY | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 protein kinase domain. Contains 1 RBD (Ras-binding) domain. |
Function | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. |
SWISS | P10398 |
Gene ID | 369 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | The RAF family of signaling proteins has three isoforms: A RAF, RAF 1 and B RAF. These proteins are instrumental in forwarding the stimulus generated by mitogens from monomeric G proteins to the MAP kinase pathway. RAF 1 is known to be downstream of Ras and binds to it by an N terminal noncatalytic domain. This domain is conserved in A RAF and B RAF. 14-3-3 is also known to be an activator of RAFs. Activated RAF directly phosphorylates and activates MEK. A RAF is expressed at a very high concentration in urogenital and kidney tissues. |