货号 |
bsm-52054R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Cytokeratin 14 antibody |
中文名称 |
Rabbit Anti-Cytokeratin 14 antibody |
产品标签 |
重组兔单抗 |
英文别名 |
Cytokeratin 14; CK 14; Cytokeratin14; Cytokeratin-14; Dowling Meara; ebs3; Epidermolysis bullosa simplex; k14; Keratin 14; Keratin type I cytoskeletal 14; Keratin14; Koebner; Krt 14; krt14; EBS3; EBS4; NFJ; Keratin, type I cytoskeletal 14; K1C14_HUMAN. |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
IHC |
产品应用(可推荐) |
ICC,IF |
推荐稀释比例 |
IHC-P=1:100-200,IHC-F=1:100-200,IF=1:100-200,ICC=1:100-200, |
克隆类型 |
单克隆 |
克隆号 |
2F11 |
抗体来源 |
Rabbit |
理论分子量 |
52 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
Recombinant human Cytokeratin 14 protein, around C-terminal 150aa |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern. |
Tissue |
Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the ge |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Heterotetramer of two type I and two type II keratins. keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins. |
Function |
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. |
Post-translational |
A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. |
DISEASE |
Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS) [MIM:131760]: A severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement. Note=Th |
SWISS |
P02533 |
Gene ID |
3861 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq]. |