货号 |
bsm-52061R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Cytokeratin 2e antibody |
中文名称 |
Rabbit Anti-Cytokeratin 2e antibody |
产品标签 |
重组兔单抗 |
研究领域 |
信号转导 |
英文别名 |
K 2e;
Cytokeratin-2e;
Epithelial keratin-2e;
K2e;
Keratin type II cytoskeletal 2 epidermal;
Keratin-2 epidermis;
KRT2; K22E_HUMAN;
KRT2A;
KRT2E;
Type-II keratin Kb2. |
反应物种(已验证) |
Human |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-1000,Elisa=1:5000-10000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,ICC=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
2F7 |
抗体来源 |
Rabbit |
理论分子量 |
70 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
Recombinant human Cytokeratin 2e protein, around 350-500aa |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasmic. |
Tissue |
Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expressi |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Heterotetramer of two type I and two type II keratins. Associates with KRT10. |
Function |
Keratins are the major gene product of keratinocytes and form the intermediate filament cytoskeletal network in these cells. In cells of the upper spinous layer, KRT2E and KRT9 are expressed. Although the expression of KRT9 is limited to palmoplantar epid |
DISEASE |
Ichthyosis bullosa of Siemens (IBS) [MIM:146800]: A rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis characterized by generalized erythema and extensive blistering from birth. Large, dark gray hyperkeratoses are obse |
SWISS |
P35908 |
Gene ID |
3849 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |