货号 |
bsm-52166R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-HSF1 (Ser326) antibody |
中文名称 |
Rabbit Anti-phospho-HSF1 (Ser326) antibody |
产品标签 |
磷酸化抗体,重组兔单抗 |
研究领域 |
肿瘤,信号转导,细胞凋亡,转录调节因子 |
英文别名 |
HSF1(S326); HSF1 (phospho S326); p-HSF1 (phospho S326); Heat shock factor 1; Heat shock factor protein 1; Heat shock transcription factor 1; HSF 1; hsf1; HSTF 1; HSTF1; HSF1_HUMAN. |
反应物种(已验证) |
Human,Rat |
反应物种(预测) |
Mouse |
产品应用(已验证) |
WB,IHC,FCM |
产品应用(可推荐) |
ICC,IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,Flow Cyt=2ug/Test,IF=1:50-200,ICC=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
37E4 |
抗体来源 |
Rabbit |
理论分子量 |
57 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human HSF1 around the phosphorylation site of Ser326 |
抗原表位 |
L(p-S)PT |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. Note=Cytoplasmic duringnormal growth. On activation, translocates to nuclear stressgranules. Colocalizes with SUMO1 in nuclear stress granules. |
SIMILARITY |
Belongs to the HSF family. |
SUBUNIT |
Monomer. Under normal conditions, interacts with HSP90AA1in the HSP90 multichaperone complex; the interaction preventstrimerization and activation of HSF1. On activation by heat-stressor by other factors such as metal ions, HSF1 is released from thecomple |
Function |
DNA-binding protein that specifically binds heat shockpromoter elements (HSE) and activates transcription. In highereukaryotes, HSF is unable to bind to the HSE unless the cells areheat shocked. |
Post-translational |
Phosphorylated on multiple serine residues, a subset of whichare involved in stress-related regulation of transcriptionactivation. Constitutive phosphorylation represses transcriptionalactivity at normal temperatures. Levels increase on specificresidues h |
SWISS |
Q00613 |
Gene ID |
3297 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008] |