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货号 | bsm-52213R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-Phospho-TrkB (Tyr817) antibody |
中文名称 | Rabbit Anti-Phospho-TrkB (Tyr817) antibody |
产品标签 | 磷酸化抗体,重组兔单抗 |
研究领域 | 肿瘤,细胞生物,免疫学,神经生物学,信号转导,转录调节因子,激酶和磷酸酶 |
英文别名 | TrkB(Y817); TrkB (phospho Y817); p-TrkB (phospho Y817); TrkB (Phospho-Tyr817); TrkB (Phospho Tyr817); TrkB (Phospho-Y817); p-TrkB(Tyr817); AI848316; BDNF tropomyosine receptor kinase B; BDNF/NT 3 growth factors receptor; BDNF/NT-3 growth factors recept |
反应物种(已验证) | Human,Mouse,Rat |
产品应用(已验证) | WB,IHC |
产品应用(可推荐) | ICC,IF |
推荐稀释比例 | WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,ICC=1:50-200, |
克隆类型 | 单克隆 |
克隆号 | 2A1 |
抗体来源 | Rabbit |
理论分子量 | 90 |
细胞定位 | 细胞浆,细胞膜 |
性状 | Liquid |
免疫原 | KLH conjugated Synthesised phosphopeptide derived from human NTRK2 around the phosphorylation site of Tyr817 |
抗原表位 | PV(p-Y)LD |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cor |
Tissue | TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain. |
SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT do |
SUBUNIT | Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation |
Function | Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for |
Post-translational | Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.
Ubiquitinated. Undergoes polyubiquitination upon activation; r |
DISEASE | Defects in NTRK2 are the cause of obesity hyperphagia and developmental delay (OHPDD) [MIM:613886]. OHPDD is a disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language. |
SWISS | Q16620 |
Gene ID | 4915 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |