货号 |
bsm-52485R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Sodium Potassium ATPase(Loading Control) antibody |
中文名称 |
Rabbit Anti-Sodium Potassium ATPase(Loading Control) antibody |
产品标签 |
内参抗体,重组兔单抗 |
研究领域 |
肿瘤,神经生物学,信号转导,通道蛋白 |
英文别名 |
ATP1A1;
alpha 1 Sodium Potassium ATPase;
A1A1;
AT1A1;
AT1A1_HUMAN;
Atpa-1;
ATPase Na+/K+ transporting alpha 1 polypeptide;
ATPase Na+/K+ transporting subunit alpha 1;
BC010319;
EC 3.6.3.9;
MGC3285;
MGC38419;
MGC51750;
Na K ATPase alpha A cata |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC,ICC,FCM |
产品应用(可推荐) |
IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:50-100,IHC-F=1:50-100,Flow Cyt=1:50,IF=1:50-100,ICC=1:50, |
克隆类型 |
单克隆 |
克隆号 |
13H5 |
抗体来源 |
Rabbit |
理论分子量 |
113 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
Recombinant human Sodium Potassium ATPase aa 1-100 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Multi-pass membrane protein. Melanosome. |
Tissue |
Found in most tissues. |
SIMILARITY |
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. |
SUBUNIT |
Interacts with SIK1. Composed of three subunits: alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1. |
Function |
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the numbe |
Post-translational |
Phosphorylation on Tyr-10 modulates pumping activity. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity. |
SWISS |
P05023 |
Gene ID |
476 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May2009]. |