货号 |
bsm-52270R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-DUSP6 antibody |
中文名称 |
Rabbit Anti-DUSP6 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
神经生物学,信号转导,激酶和磷酸酶 |
英文别名 |
Dual specificity phosphatase 6; Dual specificity phosphatase 6 isoform a; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUS6_HUMAN; DUSP 6; DUSP 6a; Dusp6; DUSP6a; MAP kinase phosphatase 3; Mitogen activated protein k |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC,ICC,FCM |
产品应用(可推荐) |
IP |
推荐稀释比例 |
WB=1:1000-5000,IP=1:20-100,IHC-P=1:50-200,IHC-F=1:50-200,Flow Cyt=1:50,ICC=1:50, |
克隆类型 |
单克隆 |
克隆号 |
9C3 |
抗体来源 |
Rabbit |
理论分子量 |
42 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
Recombinant human DUSP6 protein |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. |
SIMILARITY |
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 rhodanese domain.
Contains 1 tyrosine-protein phosphatase domain. |
Function |
Inactivates MAP kinases. Has a specificity for the ERK family. |
SWISS |
Q16828 |
Gene ID |
1848 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |