货号 |
bs-22901R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-IL-4R antibody |
中文名称 |
Rabbit Anti-IL-4R antibody |
研究领域 |
细胞生物,免疫学,细胞膜受体,细胞表面分子, |
英文别名 |
CD124;
IL 4R alpha;
IL-4 receptor subunit alpha;
IL-4-binding protein;
IL-4R subunit alpha;
IL-4R-alpha;
IL-4RA;
IL4-BP;
Il4r;
IL4R nirs variant 1;
IL4RA;
IL4RA_HUMAN;
Interleukin 4 receptor alpha chain;
Interleukin 4 receptor;
sIL4Ralpha/pr |
反应物种(已验证) |
Human |
反应物种(预测) |
protein |
产品应用(已验证) |
WB |
推荐稀释比例 |
WB=1:500-2000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
88 |
细胞定位 |
细胞膜,分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human IL-4R |
抗原表位 |
71-170/825 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. |
Tissue |
Isoform 1 and isoform 2 are highly expressed in activated T-cells. |
SIMILARITY |
Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 1 fibronectin type-III domain. |
SUBUNIT |
The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can al |
Function |
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production |
Post-translational |
On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolyt |
SWISS |
P24394 |
Gene ID |
3566 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008]. |