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货号 | bs-24335R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-MEGF10 antibody |
中文名称 | Rabbit Anti-MEGF10 antibody |
研究领域 | 细胞生物,发育生物学,干细胞,细胞凋亡,生长因子和激素,新陈代谢, |
英文别名 | MEG10_HUMAN; MEGF protein; megf10; Multiple EGF-like domains protein 10; multiple EGF-like-domains 10; Multiple epidermal growth factor-like domains 10; Multiple epidermal growth factor-like domains protein 10. |
反应物种(已验证) | Human |
反应物种(预测) | Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit,Sheep |
产品应用(已验证) | WB |
推荐稀释比例 | WB=1:500-2000, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 119 |
细胞定位 | 细胞膜 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from human MEGF10 |
抗原表位 | 1041-1140/1140 |
抗原细胞定位 | Cytoplasmic |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Cell membrane. |
SIMILARITY | Belongs to the MEGF family. Contains 15 EGF-like domains. Contains 1 EMI domain. |
SUBUNIT | Homopolymer (Probable). Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11. |
Function | Involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 during engulfment. Destabilizes the oligomeric assemblies of the ABCA1 transporter. Plays a role in cell adhesion. Inhibits cell motility and cell proliferation in vitro. Pr |
Post-translational | Phosphorylated on tyrosine residues. Ubiquinated; mono- and polyubiquitinated forms are detected. |
DISEASE | Defects in MEGF10 are the cause of myopathy, early-onset, areflexia, respiratory distress, and dysphagia (EMARDD) [MIM:614399]. An autosomal recessive congenital myopathy characterized by onset at birth, or early in infancy, of respiratory distress caused |
SWISS | Q96KG7 |
Gene ID | 84466 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | MEGF10 is a 1,140 amino acid protein encoded by the human gene MEGF10. MEGF10 belongs to the MEGF family and contains fifteen EGF-like domains and one EMI domain. The engulfment of dying cells is a specialized form of phagocytosis that is highly conserved across evolution and is mediated by the concerted action of several molecules. MEGF10 is an engulfment receptor protein that localizes to the plasma membrane in a punctuated pattern. The MEGF10 protein shares structural similarities with nematode engulfment receptor cell death abnormal-1 (CED-1). MEGF10 function is modulated by the ATP binding cassette transporter ABCA1, which is an ortholog to CED-7. It is expressed at the cell surface in clusters around cell corpses during engulfment, and during the engulfment of apoptotic thymocytes is recruited to the bottom of the forming phagocytic cup. |