货号 |
bsm-54221R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Uteroglobin antibody |
中文名称 |
Rabbit Anti-Uteroglobin antibody |
产品标签 |
重组兔单抗 |
研究领域 |
细胞生物,免疫学 |
英文别名 |
blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell phospholipid binding protein; Clara cell phospholipid-binding protein; clara cell secretory protein; Clara cell specific 10 kD protein; Clara Cells 10 kDa Secretory Protein; OTTHUMP00000236107; Secretoglobi |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ICC |
推荐稀释比例 |
WB=1:500-1000,ICC=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
7G5 |
抗体来源 |
Rabbit |
理论分子量 |
8 |
细胞定位 |
分泌型蛋白 |
性状 |
Liquid |
免疫原 |
Recombinant human Uteroglobin |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Secreted. |
Tissue |
Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways). |
SIMILARITY |
Belongs to the secretoglobin family. |
SUBUNIT |
Homodimer; antiparallel disulfide-linked. |
Function |
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. |
SWISS |
P11684 |
Gene ID |
7356 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion. |